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8-苯基茶碱

8-苯基茶碱名称

[ CAS 号 ]:
961-45-5

[ 中文名 ]:
8-苯基茶碱

[ 英文名 ]:
8-PHENYLTHEOPHYLLINE

[英文别名 ]:

1,3-dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione
Theophylline,8-phenyl
MFCD00005582
Lopac-P-2278
1,3-dimethyl-7-phenylxanthine
1,3-dimethyl-8-phenyl-3,7-dihydro-purine-2,6-dione
8-Phenyltheophylline
1,3-Dimethyl-8-phenylxanthine

8-苯基茶碱物理化学性质

[ 密度 ]:
1.361g/cm3

[ 沸点 ]:
517.7ºC at 760mmHg

[ 熔点 ]:
>300ºC(lit.)

[ 分子式 ]:
C₁₃H₁₂N₄O₂

[ 分子量 ]:
256.26000

[ 闪点 ]:
266.9ºC

[ 精确质量 ]:
256.09600

[ PSA ]:
72.68000

[ LogP ]:
0.62730

[ 折射率 ]:
1.639

8-苯基茶碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8445700

CHEMICAL NAME :: 1H-Purine-2,6-dione, 2,3,6,7-tetrahydro-1,3-dimethyl-8-phenyl-

CAS REGISTRY NUMBER :: 961-45-5

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-N4-O2

MOLECULAR WEIGHT :: 256.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,152,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5032593

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8-苯基茶碱安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UO8445700

[ 海关编码 ]:
2933990090

8-苯基茶碱上下游产品

8-苯基茶碱上游产品

8-苯基茶碱下游产品

8-苯基茶碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-苯基茶碱文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia.

Mol. Med. Report. 11 , 4397-402, (2015)

Fibroblasts are the effector cells of collagen secretion in renal interstitial fibrosis (RIF), and their proliferation and activation are essential for the development of RIF. Hypoxic ischemia in loca...

Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature.

J. Mol. Cell. Cardiol. 52(5) , 962-70, (2012)

ATP can differentially affect the micro- and macrovascular endothelial barrier. It has been shown that it can both increase and/or decrease macromolecule permeability of microvascular endothelial cell...

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