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黄嘌呤胺同类物

黄嘌呤胺同类物用途

黄嘌呤胺同系物是一种非选择性腺苷受体拮抗剂[1]。黄嘌呤胺同系物诱导小鼠惊厥[2]。

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黄嘌呤胺同类物名称

[ CAS 号 ]:
96865-92-8

[ 中文名 ]:
黄嘌呤胺同类物

[ 英文名 ]:
Xanthine amine congener

[英文别名 ]:

Papaxac
XAC
Lopac-X-103
xanthine amine congener
Xanthine amine congener xac

黄嘌呤胺同类物生物活性

[ 描述 ]:

黄嘌呤胺同系物是一种非选择性腺苷受体拮抗剂[1]。黄嘌呤胺同系物诱导小鼠惊厥[2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[参考文献]

[1]. Ukena D, et al. Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells. Life Sci. 1986 Mar 3;38(9):797-807.

黄嘌呤胺同类物物理化学性质

[ 密度 ]:
1.262g/cm3

[ 分子式 ]:
C₂₁H₂₈N₆O₄

[ 分子量 ]:
428.48

[ 精确质量 ]:
428.21700

[ PSA ]:
137.03000

[ LogP ]:
1.91820

[ 折射率 ]:
1.586

[ 储存条件 ]:
-20°C，密闭，干燥

黄嘌呤胺同类物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

黄嘌呤胺同类物文献

Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.

Mol. Pharmacol. 87(1) , 39-51, (2015)

Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of recept...

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

FASEB J. 25(10) , 3465-76, (2011)

A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as homodimers, but the extent of the cooperativity across the dimer interface has been largely unexplored. Here, measu...

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Neurobiol. Dis. 74 , 41-57, (2015)

Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechani...

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