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氧氯丙嗪

氧氯丙嗪名称

[ CAS 号 ]:
969-99-3

[ 中文名 ]:
氧氯丙嗪

[ 英文名 ]:
Oxychlorpromazine

[英文别名 ]:

Chlorpromazine sulphoxide
Opromazine
Chlorpromazine-S-oxyd
Oxychlorpromazine
Chloropromazine sulfoxide
Opromazin
Transedon
Chlorpromazine sulfoxide
Chlorpromazine-S-oxide
Secotil

氧氯丙嗪物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
502.6ºC at 760 mmHg

[ 熔点 ]:
115°

[ 分子式 ]:
C₁₇H₁₉ClN₂OS

[ 分子量 ]:
334.86400

[ 闪点 ]:
257.8ºC

[ 精确质量 ]:
334.09100

[ PSA ]:
42.76000

[ LogP ]:
4.84060

[ 折射率 ]:
1.687

氧氯丙嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO2275000

CHEMICAL NAME :: Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, sulfoxide

CAS REGISTRY NUMBER :: 969-99-3

BEILSTEIN REFERENCE NO. :: 0307255

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H19-Cl-N2-O-S

MOLECULAR WEIGHT :: 334.89

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EG IO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 163 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,328,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 8,50,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,71S,1957

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氧氯丙嗪文献

[Simultaneous determination of chlorpromazine and promethazine and their main metabolites by capillary electrophoresis with electrochemiluminescence].

Se Pu 30(9) , 938-42, (2012)

Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) inte...

Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.

Photochem. Photobiol. 44(1) , 5-10, (1986)

Involvement of erythrocyte skeletal proteins in the modulation of membrane fluidity by phenothiazines.

Biochemistry 26(25) , 8133-7, (1987)

The effects of phenothiazines (chlorpromazine, chlorpromazine sulfoxide, and trifluoperazine) and antimitotic drugs (colchicine and vinblastine) on the erythrocyte membrane have been investigated. Chl...

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