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BML-266

BML-266用途

JFD00244 是一种 sirtuin 2 (SIRT2) 抑制剂。抗肿瘤作用。

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BML-266名称

[ CAS 号 ]:
96969-83-4

[ 英文名 ]:
BML-266

[英文别名 ]:

1,4-bis[(p-hydroxyphenethyl)amino]-anthraquinone
hms3261l04

BML-266生物活性

[ 描述 ]:

JFD00244 是一种 sirtuin 2 (SIRT2) 抑制剂。抗肿瘤作用。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> 抗衰老酶

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶

[参考文献]

[1]. Ciarlo C, A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 Aug 23;6. pii: e29145.

BML-266物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
780.2±60.0 °C at 760 mmHg

[ 分子式 ]:
C₃₀H₂₆N₂O₄

[ 分子量 ]:
478.538

[ 闪点 ]:
425.7±32.9 °C

[ 精确质量 ]:
478.189270

[ PSA ]:
98.66000

[ LogP ]:
4.45

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.733

[ 储存条件 ]:
-20°C

BML-266MSDS

详细MSDS(安全技术说明书)

BML-266安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

BML-266文献

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

J. Med. Chem. 47 , 6292-6298, (2004)

Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in ...

Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.

J. Med. Chem. 49 , 7239-7241, (2006)

A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level,...

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