< 生产厂家价格 >

佩西立文

佩西立文用途

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱,具有抗癌作用。

点击显示

佩西立文名称

[ CAS 号 ]:
975-77-9

[ 中文名 ]:
佩西立文

[ 英文名 ]:
Pericyclivine

[英文别名 ]:

pericyclivine
Pericyclivin
Desformoakuammidin
Sarpagan-17-oic acid, methyl ester, (15α)-
Methyl (15α,19E)-sarpagan-17-oate
sarpagan-17-oic acid methyl ester
Deformoakuammidine

佩西立文生物活性

[ 描述 ]:

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱,具有抗癌作用。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

周环藤对P-388细胞培养体系具有细胞毒性,ED50为13μg/mL[2]。

[参考文献]

[1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

[2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

佩西立文物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
489.2±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₂N₂O₂

[ 分子量 ]:
322.401

[ 闪点 ]:
249.7±28.7 °C

[ 精确质量 ]:
322.168121

[ PSA ]:
45.33000

[ LogP ]:
3.50

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.673

[ 储存条件 ]:
2-8℃，干燥，密闭

佩西立文毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VQ5835000

CHEMICAL NAME :: Sarpagan-17-oic acid, methyl ester, (16S)-

CAS REGISTRY NUMBER :: 975-77-9

LAST UPDATED :: 197905

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H20-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04199