美屈孕酮
美屈孕酮名称
[ CAS 号 ]:
977-79-7
[ 中文名 ]:
美屈孕酮
[ 英文名 ]:
Medrogestone
[中文别名 ]:
[英文别名 ]:
- EINECS 213-555-0
- 4,6-PREGNADIEN-6,17-DIMETHYL-3,20-DIONE
- 6,17-Dimethyl-4,6-pregnadien-3.20-dion
- MFCD00271888
- 6,17-Dimethyl-pregnadien-(4,6)-dion-(3.20)
- 6,17-Dimethyl-pregna-4,6-dien-3.20-dion
- 6,17-dimethylpregna4,6-diene-3,20-dione
美屈孕酮物理化学性质
[ 密度 ]:
1.08g/cm3
[ 沸点 ]:
467.2ºC at 760mmHg
[ 分子式 ]:
C23H32O2
[ 分子量 ]:
340.49900
[ 闪点 ]:
173.7ºC
[ 精确质量 ]:
340.24000
[ PSA ]:
34.14000
[ LogP ]:
5.27970
[ 折射率 ]:
1.549
美屈孕酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3832300
- CHEMICAL NAME :
- Pregna-4,6-diene-3,20-dione, 6,17-dimethyl-
- CAS REGISTRY NUMBER :
- 977-79-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C23-H32-O2
- MOLECULAR WEIGHT :
- 340.55
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4230702 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20500 ug/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 15-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 26250 ug/kg
- SEX/DURATION :
- female 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 7500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,473,1966
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