链球菌溶血素O 来源于化脓链球菌

链球菌溶血素O 来源于化脓链球菌用途

Streptolysin O,A组链球菌毒素,是一个氧不稳定原型胆固醇结合细菌外毒素。Streptolysin O 导致细胞裂解和心脏毒性。Streptolysin O 用于细胞膜的可控渗透性。Streptolysin O 以两种形式存在,即还原活性状态和氧化可逆不活动状态。

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链球菌溶血素O 来源于化脓链球菌名称

[ CAS 号 ]:
98072-47-0

[ 中文名 ]:
链球菌溶素O

[ 英文名 ]:
Streptolysin O

[英文别名 ]:

EINECS 308-500-3

链球菌溶血素O 来源于化脓链球菌生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[体外研究]

当Streptolysin O被链球菌分泌时,它处于活性状态,但它迅速形成可逆的非活性状态,形成二硫键〔2〕。Streptolysin O属于巯基活化毒素组,是一种分泌性毒力因子,在中性粒细胞和巨噬细胞中诱导凋亡,在随后的时间点(～4小时)。链球菌溶血素O以胆固醇依赖的方式诱导真核细胞裂解,在血流传播过程中GAS M1T1克隆高度上调。已知链球菌溶血素O能促进A组链球菌(GAS)抵抗中性粒细胞吞噬清除,中性粒细胞是宿主抵抗侵袭性细菌感染的关键第一要素[3]。

[参考文献]

[1]. Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71(1):446-55.

[2]. Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3(5):648-52.

[3]. Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581.

[4]. Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65(12):2682-9.

链球菌溶血素O 来源于化脓链球菌物理化学性质

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble1mg/mL

链球菌溶血素O 来源于化脓链球菌安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
UN 2811PIH 6.1 / PGI

[ WGK德国 ]:
3

链球菌溶血素O 来源于化脓链球菌文献

Suicide cancer gene therapy using pore-forming toxin, streptolysin O.

Mol. Cancer Ther. 5 , 1610-1619, (2006)

We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently ...

Inhibition of streptolysin O by allicin - an active component of garlic.

J. Med. Microbiol. 59 , 1044-1049, (2010)

Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated...

Neurotransmitter interactions related to central dopamine neurons.

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