正丁酰基-DL-高丝氨酸内酯

正丁酰基-DL-高丝氨酸内酯用途

N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) 是一种群体感应 (QS) 信号分子。N-Butanoyl-DL-homoserine lactone 适配体可用于阻止群体感应和抑制铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成。

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正丁酰基-DL-高丝氨酸内酯名称

[ CAS 号 ]:
98426-48-3

[ 中文名 ]:
2-氨基-4-磺酸基苯甲酸

[ 英文名 ]:
N-Butanoyl-DL-homoserine lactone

[英文别名 ]:

MFCD018629

正丁酰基-DL-高丝氨酸内酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体外研究]

与正丁醇-DL-高丝氨酸内酯结合的适体的离解常数(Kd值)为28.47nm[1]。

[参考文献]

[1]. Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041.

正丁酰基-DL-高丝氨酸内酯物理化学性质

[ 分子式 ]:
C₈H₁₃NO₃

[ 分子量 ]:
171.19400

[ 精确质量 ]:
171.09000

[ PSA ]:
55.40000

[ LogP ]:
0.60910

[ 储存条件 ]:
2-8℃

正丁酰基-DL-高丝氨酸内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

正丁酰基-DL-高丝氨酸内酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

正丁酰基-DL-高丝氨酸内酯文献

Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

Microbiology 143 , 3703, (1997)

Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional activator protein to couple gene expression with cell population density. In Gram-negative bacteria, s...

Detection of acyl-homoserine lactones by Escherichia and Salmonella.

Curr. Opin. Microbiol. 14 , 188-193, (2011)

Escherichia and Salmonella do not synthesize quorum-sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs produced by other species of bacteria. AHLs are p...

N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria.

Syst. Appl. Microbiol. 22 , 493-506, (1999)

The view of bacteria as unicellular organisms has strong roots in the tradition of culturing bacteria in liquid media. However, in nature microbial activity is mainly associated with surfaces where ba...

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