对氨基-N,N-二甲基苯胺
对氨基-N,N-二甲基苯胺用途
用作医药、偶氮染料、显影剂及农药等的原料
【用途二】
N，N-甲基对苯二胺是杀菌剂敌磺钠的中间体。
【用途三】
为测定钒的试剂。用于染料、农药和显影剂的生产。对氨基二甲苯胺和对异硫氰基苯丁醚加成可得抗麻疯病药丁氨苯硫脲。
【用途四】
光谱测定SO42-, S2-、V的试剂。
对氨基-N,N-二甲基苯胺名称
[ CAS 号 ]:
99-98-9
[ 中文名 ]:
N,N-二甲基-对苯二胺
[ 英文名 ]:
N,N-Dimethyl-1,4-benzenediamine
[中文别名 ]:
[英文别名 ]:
- N,N-DIMETHYL-P-PHENYLENEDIAMINE
- N,N-Dimethyl-1,4-benzenediamine
- EINECS 202-807-5
- N,N-Dimethylbenzene-1,4-diamine
- 4-N,4-N-dimethylbenzene-1,4-diamine
- 1,4-Benzenediamine, N,N-dimethyl-
- N,N-Dimethyl-1,4-phenylenediamine
- MFCD00007860
对氨基-N,N-二甲基苯胺物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
262.0±0.0 °C at 760 mmHg
[ 熔点 ]:
34-36 °C(lit.)
[ 分子式 ]:
C8H12N2
[ 分子量 ]:
136.194
[ 闪点 ]:
90.6±0.0 °C
[ 精确质量 ]:
136.100052
[ PSA ]:
29.26000
[ LogP ]:
0.75
[ 外观性状 ]:
淡棕色固体或液体
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.607
[ 储存条件 ]:
2-8°C
[ 稳定性 ]:
Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents. Combustible.
[ 水溶解性 ]:
11 g/L (20 ºC)
对氨基-N,N-二甲基苯胺MSDS
对氨基-N,N-二甲基苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ST0874000
- CHEMICAL NAME :
- p-Phenylenediamine, N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 99-98-9
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 27
- MOLECULAR FORMULA :
- C8-H12-N2
- MOLECULAR WEIGHT :
- 136.22
- WISWESSER LINE NOTATION :
- ZR DN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 14 ug/kg
- TOXIC EFFECTS :
- Blood - hemorrhage Skin and Appendages - primary irritation (after topical exposure) Skin and Appendages - dermatitis, allergic (after topical exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 500 ppb
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 240 ppb
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 649 mg/kg/11D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7141 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 50 (estimated) No. of Female Employees: 50 (estimated)
对氨基-N,N-二甲基苯胺安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H311 + H331
[ 警示性声明 ]:
P261-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38
[ 安全声明 (欧洲) ]:
S28-S45-S36/37/39-S26
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
ST0874000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2818300000
对氨基-N,N-二甲基苯胺合成路线
对氨基-N,N-二甲基苯胺上下游产品
对氨基-N,N-二甲基苯胺上游产品
对氨基-N,N-二甲基苯胺下游产品
对氨基-N,N-二甲基苯胺制备
1. 以二甲苯胺为原料，经亚硝化，还原而得，反应式如下：
工艺过程：（1）亚硝化 将稀盐酸及二甲基苯胺搅匀冷却至5℃以下，加亚硝酸钠溶液进行亚硝化，加毕，放置，过滤结晶，用1：1盐酸洗，再用盐酸与酒精的混合液再洗涤一次，抽干，得亚硝化物。（2）还原 将上述粗品有水搅拌成糊状，再加工业浓盐酸，外面用冰水冷却，慢慢加入锌粉，加入温度不宜超过45℃。（3）提取 加氢氧化钠溶液至碱性后，再用苯提取，苯溶液用无水碳酸钾干燥，用水浴回收苯，再减压蒸馏收集成品。其它制法由甲基橙还原或由对硝基二甲基苯胺用硫化钠或硫化钾还原而制得。工业上用香兰素萃取后废液为原料，经中和、萃取、蒸馏而得。该品对皮肤有刺激性，毒性比对苯二胺大8倍。
2. 其制备方法是用N，N-二甲苯胺与亚硝酸钠和盐酸进行亚硝化，再在铁粉和盐酸存在下进行还原，得到的N，N-二甲基对苯二胺盐酸盐用碱中和得产品。
也可以从香豆素生产中的废水用氨水中和至pH=7～8，加热至约40℃，沉淀8～12h，清除沉淀渣，用苯萃取中和液，然后减压脱苯即得N，N-二甲基对苯二胺。
对氨基-N,N-二甲基苯胺海关
[ 海关编码 ]: 2921590090
[ 中文概述 ]:
2921590090. 其他芳香多胺及衍生物及它们的盐. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
对氨基-N,N-二甲基苯胺文献
Talanta 147 , 531-6, (2015)
A multicommuted flow injection method has been developed for the determination of phenolic species in virgin olive oil samples. The method is based on the inhibitory effect of antioxidants on a stable...
Aniline-modified porous graphitic carbon for hydrophilic interaction and attenuated reverse phase liquid chromatography.J. Chromatogr. A. 1373 , 17-24, (2014)
Most stationary phases for hydrophilic interaction liquid chromatography (HILIC) and reversed phase liquid chromatography (RPLC) are based on silica. Porous graphitic carbon (PGC) is an attractive alt...
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Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting...
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