防御素 Np1

防御素 Np1用途

人防御素HNP-1是人中性粒细胞肽(HNPs),参与动脉粥样硬化早期内皮细胞功能障碍发育。防御素HNP-1可调节动脉粥样硬化的生长。

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防御素 Np1名称

[ CAS 号 ]:
99287-08-8

[ 中文名 ]:
防御素 Np1

[ 英文名 ]:
Defensin HNP-1 human

[英文别名 ]:

HNP-1, Defensin Human Neutrophil Peptide-1

防御素 Np1生物活性

[ 描述 ]:

人防御素HNP-1是人中性粒细胞肽(HNPs),参与动脉粥样硬化早期内皮细胞功能障碍发育。防御素HNP-1可调节动脉粥样硬化的生长。

[ 靶点 ]

Human Endogenous Metabolite

防御素 Np1物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₅₀H₂₂₈N₄₄O₃₈S₆

[ 分子量 ]:
3442.030

[ 精确质量 ]:
3439.511475

[ LogP ]:
-8.95

[ 折射率 ]:
1.703

防御素 Np1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

防御素 Np1文献

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37.

Infect. Immun. 83 , 4701-9, (2015)

Chlamydia trachomatis infection in the lower genital tract can ascend to and cause pathologies in the upper genital tract, potentially leading to severe complications, such as tubal infertility. Howev...

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps.

Biochem. J. 464(1) , 3-11, (2014)

NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. ...

Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium.

Eur. Respir. J. 12 , 1200-1208, (1998)

Neutrophils have the capacity to accumulate in high numbers in the lung during infection and inflammation. Because they play an important role in host defence against infection, but may also cause tis...

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