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硼烷二甲硫醚

硼烷二甲硫醚用途

【用途一】
硼烷二甲硫醚络合物(13292-87-0)与蒎烯13126配套使用用于生产孟鲁司特钠以及恩替卡韦.

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硼烷二甲硫醚名称

[ CAS 号 ]:
13292-87-0

[ 中文名 ]:
硼烷二甲硫醚络合物

[ 英文名 ]:
Di-methylsulfide borane

[中文别名 ]:

[英文别名 ]:

Methyl sulfide, compd. with borane (1:1)
DiMethyl Sulfide Borane
Dimethyl sulphide borane
EINECS 236-313-6
(Methylsulfanyl)methane - borane (1:1)
BMS Trihydro[thiobis[methane]]boron
Borane, compd. with 1,1'-thiobis[methane] (1:1)
BMS,Trihydro[thiobis[methane]]boron
boron,methylsulfanylmethane
Borane - Dimethyl Sulfide Complex

硼烷二甲硫醚物理化学性质

[ 密度 ]:
1.287 g/mL at 25 °C

[ 沸点 ]:
~34 °C

[ 熔点 ]:
-40--37°C

[ 分子式 ]:
C₂H₉BS

[ 分子量 ]:
75.969

[ 闪点 ]:
65 °F

[ 精确质量 ]:
76.051804

[ PSA ]:
25.30000

[ 外观性状 ]:
透明无色至淡黄色溶液

[ 折射率 ]:
1.4570

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
起反应

硼烷二甲硫醚MSDS

硼烷二甲硫醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PV5080000

CAS REGISTRY NUMBER :: 13292-87-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C2-H9-B-S

MOLECULAR WEIGHT :: 75.98

WISWESSER LINE NOTATION :: 1S1 &.B-H3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972- Volume(issue)/page/year: 9,4,1980 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972- Volume(issue)/page/year: 9,4,1980

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硼烷二甲硫醚安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H260-H302-H318

[ 补充危害声明 ]:
May form explosive peroxides., Reacts violently with water.

[ 警示性声明 ]:
P210-P223-P231 + P232-P280-P370 + P378-P422

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R14/15;R21;R36;R40

[ 安全声明 (欧洲) ]:
S36/37-S62-S36/39-S33-S26-S23-S16-S36-S24/25-S7/8

[ 危险品运输编码 ]:
UN 3399 4.3/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
PV5080000

[ 包装等级 ]:
II

[ 危险类别 ]:
4.3

硼烷二甲硫醚合成路线

硼烷二甲硫醚上下游产品

硼烷二甲硫醚上游产品

硼烷二甲硫醚下游产品

硼烷二甲硫醚制备

1. 在氮气存在下，10毫升甲硫醚与等体积的乙硼烷气体一起冷凝于一个可浸式张力计中。温热至室温后，再将此混合物冷到一78℃，以除去过量的乙硼烷(计5.1毫升)。

2. 在氮气存在下，将现场制备的乙硼烷经纯化后，在0℃下用甲硫醚直接吸收而成。

3. 通过将硼氢化钠与三氟化硼的乙醚配合物溶于二甘醇二甲醚，并向溶液中通入甲硫醚而制得。

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硼烷二甲硫醚文献

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma.

Sci. Signal. 8 , ra82, (2015)

Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein kinase kinase (MEK), co...

[Safe use of biological therapies for the treatment of rheumatoid arthritis and spondyloarthritides].

Rev. Bras. Reumatol. 55 , 281-309, (2015)

The treatment of autoimmune rheumatic diseases has gradually improved over the last half century, which has been expanded with the contribution of biological therapies or immunobiopharmaceuticals. How...

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

Nat. Commun. 5 , 5712, (2014)

Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is a...

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硼烷二甲硫醚

硼烷二甲硫醚用途

硼烷二甲硫醚名称

硼烷二甲硫醚物理化学性质

硼烷二甲硫醚MSDS

详细MSDS(安全技术说明书)

硼烷二甲硫醚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硼烷二甲硫醚安全信息

硼烷二甲硫醚合成路线

详细合成路线

硼烷二甲硫醚上下游产品

硼烷二甲硫醚上游产品

硼烷二甲硫醚下游产品

硼烷二甲硫醚制备

硼烷二甲硫醚文献

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