NSC363998 free base

• 常用名: NSC363998 free base
• 英文名: NSC363998 free base
• CAS号: 159357-82-1
• 分子量: 440.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₂N₄O₄
• 熔点: N/A
• 闪点: N/A

NSC363998 free base用途

NSC363998(游离碱)是一种口服活性化合物。NSC363998(游离碱)能抑制rGG90诱导的神经毒性。NSC363998(游离碱)可用于神经退行性疾病的研究,如脆性X相关震颤/共济失调综合征(FXTAS)[1]。

NSC363998 free base名称

• 英文名: NSC363998 free base

NSC363998 free base生物活性

• 描述: NSC363998(游离碱)是一种口服活性化合物。NSC363998(游离碱)能抑制rGG90诱导的神经毒性。NSC363998(游离碱)可用于神经退行性疾病的研究,如脆性X相关震颤/共济失调综合征(FXTAS)[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: NSC363998(游离碱)(口服；0.5μM)可抑制rGG90诱导的神经毒性[1]。动物模型：FXTAS果蝇模型[1]剂量：0,5μM给药：口服(溶解在DMSO中并添加到标准食品中)结果：可以改变FXTAS小鼠模型中的小眼退化并降低neddylation活性。
• 参考文献:

  [1]. Yunting Lin, et al. Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima. Neurobiol Dis. 2020 Sep;143:105013.

NSC363998 free base物理化学性质

• 分子式: C₂₄H₃₂N₄O₄
• 分子量: 440.54
• InChIKey: ZDFMCUHFIYMYTO-UHFFFAOYSA-N
• SMILES: O=C1c2cccc(NCCCNCCO)c2C(=O)c2cccc(NCCCNCCO)c21

NSC363998 free base靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Single Concentration Validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U... 来源：Burnham Center for Chemical Genomics 靶标：COP9 signalosome complex subunit 5 [Homo sapiens] External Id：SBCCG-A995-CSN5-CP-Assay

实验名称：Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase H... 来源：Burnham Center for Chemical Genomics 靶标：72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] External Id：SBCCG-A996-CSN5-MMP2-CP-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U... 来源：Burnham Center for Chemical Genomics 靶标：TPA: prothrombin [Bos taurus] External Id：SBCCG-A997-CSN5-thrombin-CP-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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