替那唑唑

• 常用名: 替那唑唑
• 英文名: Tinazoline
• CAS号: 62882-99-9
• 分子量: 217.29000
• 密度: 1.42g/cm3
• 沸点: 437.6ºC at 760 mmHg
• 分子式: C₁₁H₁₁N₃S
• 熔点: N/A
• 闪点: 218.4ºC

替那唑唑用途

Tinazoline,咪唑衍生物,是一种血管收缩剂。Tinazoline可作为鼻减充血剂用于普通感冒的研究。

替那唑唑名称

• 中文名: 替那唑唑
• 英文名: 3-(4,5-Dihydro-1H-imidazol-2-ylsulfanyl)-1H-indole

替那唑唑生物活性

• 描述: Tinazoline,咪唑衍生物,是一种血管收缩剂。Tinazoline可作为鼻减充血剂用于普通感冒的研究。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Nagarajan K, et al. Structure activity relations among cyclic & acyclic S-(3-indolyl) isothioureas-development of a potent vasoconstrictor, tinazoline, 3-(2-imidazolin-2-yl-thio)indole. Indian J Exp Biol. 1981 Dec;19(12):1150-3.

替那唑唑物理化学性质

• 密度: 1.42g/cm3
• 沸点: 437.6ºC at 760 mmHg
• 分子式: C₁₁H₁₁N₃S
• 分子量: 217.29000
• 闪点: 218.4ºC
• 精确质量: 217.06700
• PSA: 65.48000
• LogP: 1.98360
• InChIKey: JENBDJGHNIOHAJ-UHFFFAOYSA-N
• SMILES: c1ccc2c(SC3=NCCN3)c[nH]c2c1
• 折射率: 1.755

替那唑唑靶点实验

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实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

实验名称：Compound was evaluated for inhibition of human PDE4A in an in vitro cell free assay m... 来源：ChEMBL 靶标：3',5'-cyclic-AMP phosphodiesterase 4A External Id：CHEMBL5291857

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替那唑唑英文别名

• 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-benzo[d]isoxazole,monohydrochloride
• 3-(2-Imidazolin-2-yl)methyl-1,2-benzisoxazole hydrochloride
• 3-(2-imidazolin-2-ylthio)-indole
• 3-(2-Imidazolin-2-ylthio)-indol
• 3-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-indole