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84082-64-4

84082-64-4 structure
84082-64-4 structure

Name Gastron
Synonyms Gastric Mucin
EINECS 282-010-7
Description Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.
Related Catalog
In Vitro Gastric mucin may be integrally involved in the mechanism of gastric mucosal injury caused by Helicobacter pylori leading to gastritis, peptic ulceration, and possibly gastric cancer[1]. Gastric mucins are classified into two types based on their histochemical properties. The first is a surface mucous cell-type mucin, secreted from the surface mucous cells. The second is found in deeper portions of the mucosa and is secreted by gland mucous cells, including mucous neck cells, cardiac gland cells, and pyloric gland cells. The unique O-glycans in gastric mucin appears to function as a natural antibiotic, protecting the host from H. pylori infection[2]. Gastric mucin may provide protection to the surface epithelium gastrointestinal tract by scavenging oxidants produced within the lumen; however, it does so at the expense of its viscoelastic properties. Both native and pronase-treated mucin effectively scavenge hydroxyl radical and that the scavenging properties are not significantly different. The effective concentration of mucin required for a 50% reduction in malondialdehyde production is 10 mg/mL for both native and pronase-treated mucin[3].
References

[1]. Toribara NW, et al. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem. 1993 Mar 15;268(8):5879-85.

[2]. Kawakubo M, et al. Natural antibiotic function of a human gastric mucin against Helicobacter pyloriinfection. Science. 2004 Aug 13;305(5686):1003-6.

[3]. Grisham MB, et al. Interaction between oxygen radicals and gastric mucin. Am J Physiol. 1987 Jul;253(1 Pt 1):G93-6.

Appearance partially purified powder
Storage condition 2-8°C
Water Solubility 1 M NaOH: soluble20mg/mL
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3