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依普利酮

依普利酮用途

Eplerenone是醛固酮拮抗剂,IC50为360nM。

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依普利酮名称

[ CAS 号 ]:
107724-20-9

[ 中文名 ]:
依普利酮

[ 英文名 ]:
Eplerenone

[中文别名 ]:

伊普利酮

[英文别名 ]:

Inspra
EplerenoneC24H3006
Elperenone
Epleremone
epoxymexrenone
Eplerenone
EPLERINONE

依普利酮生物活性

[ 描述 ]:

Eplerenone是醛固酮拮抗剂,IC50为360nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 盐皮质激素受体

研究领域 >> 心血管疾病

[参考文献]

[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25.

[2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.

[相关活性小分子]

依普利酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
597.9±50.0 °C at 760 mmHg

[ 熔点 ]:
241-243ºC

[ 分子式 ]:
C₂₄H₃₀O₆

[ 分子量 ]:
414.491

[ 闪点 ]:
259.5±30.2 °C

[ 精确质量 ]:
414.204254

[ PSA ]:
82.20000

[ LogP ]:
1.05

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.587

[ 储存条件 ]:
0-10°C;避免加热

[ 水溶解性 ]:
水溶性：实际上不溶；可溶于：氯仿,二氯甲烷；微溶：乙醇；极微溶：甲醇

依普利酮MSDS

依普利酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
3077

[ 海关编码 ]:
29322090

依普利酮合成路线

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依普利酮文献

Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library.

Altern. Lab. Anim. 42(4) , 235-43, (2014)

Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research co...

Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension.

Am. J. Physiol. Heart Circ. Physiol. 309 , H1987-96, (2015)

The aim of the present study was to determine whether long-term high salt intake in the drinking water induces hypertension in wild-type (WT) mice and whether a chymase inhibitor or other antihyperten...

The Other Side of the RAAS: Aldosterone Improves Migration of Cardiac Progenitor Cells.

J. Cell Physiol. 230 , 2829-36, (2015)

Stem cell therapy is a promising new option for patients suffering from heart failure. Though many clinical studies show encouraging results, little is known about the signals which cause stem cells t...

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