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醋酸去氧皮质酮

醋酸去氧皮质酮用途

Deoxycorticosterone 醋酸盐是一种肾上腺皮质素, 作为前体醛固酮。

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醋酸去氧皮质酮名称

[ CAS 号 ]:
56-47-3

[ 中文名 ]:
醋酸去氧皮质酮

[ 英文名 ]:
Deoxycorticosterone acetate

[中文别名 ]:

[英文别名 ]:

21-Acetyloxypregn-4-ene-3,20-dione
DOXO
Descotone
Deoxycostone Acetate
Pregn-4-ene-3,20-dione, 21- (acetyloxy)-
3,20-Dioxopregn-4-en-21-ylacetat
Desoxycorticosterone acetate (USP)
Doca
Syncort
3,20-Dioxopregn-4-en-21-yl acetate

醋酸去氧皮质酮生物活性

[ 描述 ]:

Deoxycorticosterone 醋酸盐是一种肾上腺皮质素, 作为前体醛固酮。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 盐皮质激素受体

研究领域 >> 内分泌

[相关活性小分子]

醋酸去氧皮质酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
504.1±50.0 °C at 760 mmHg

[ 熔点 ]:
157°C

[ 分子式 ]:
C₂₃H₃₂O₄

[ 分子量 ]:
372.498

[ 闪点 ]:
218.0±30.2 °C

[ 精确质量 ]:
372.230072

[ PSA ]:
60.44000

[ LogP ]:
4.53

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.542

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
H2O: insoluble

醋酸去氧皮质酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HG0525000

CHEMICAL NAME :: 11-Deoxycorticosterone, acetate

CAS REGISTRY NUMBER :: 56-47-3

BEILSTEIN REFERENCE NO. :: 2570798

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C23-H32-O4

MOLECULAR WEIGHT :: 372.55

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A F FV1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 83,14,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1258 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 28,129,1941

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 316 mg/kg

SEX/DURATION :: female 56 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 120,238,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 224 mg/kg

SEX/DURATION :: female 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 120,238,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 16 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 17,432,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5546 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 968 (estimated) No. of Female Employees: 494 (estimated)

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醋酸去氧皮质酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
HG0525000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

醋酸去氧皮质酮合成路线

详细合成路线

醋酸去氧皮质酮上下游产品

醋酸去氧皮质酮上游产品

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醋酸去氧皮质酮制备

黄体酮在四氢呋喃和甲醇混合溶液中与氧化钙和碘发生碘代反应，再与醋酸钾在无水丙酮中反应成酯，最后精制而得。

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醋酸去氧皮质酮文献

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Toxicol. Mech. Methods 18 , 217-27, (2008)

ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...

Antibacterial activity of enrofloxacin and ciprofloxacin derivatives of β-octaarginine.

Chem. Biodivers. 12(2) , 179-93, (2015)

β(3) -Octaarginine chains were attached to the functional groups NH and CO2 H of the antibacterial fluoroquinolones ciprofloxacin (→1) and enrofloxacin (→2), respectively, in order to find out whether...

Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats.

Psychopharmacology 223(3) , 307-17, (2012)

Vascular dementia and hypertension are increasing day by day, with a high degree of co-occurrence. Tremendous amount of research work is required so that new pharmacological agents may be identified f...

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醋酸去氧皮质酮

醋酸去氧皮质酮用途

醋酸去氧皮质酮名称

醋酸去氧皮质酮生物活性

醋酸去氧皮质酮物理化学性质

醋酸去氧皮质酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

醋酸去氧皮质酮安全信息

醋酸去氧皮质酮合成路线

详细合成路线

醋酸去氧皮质酮上下游产品

醋酸去氧皮质酮上游产品

醋酸去氧皮质酮下游产品

醋酸去氧皮质酮制备

醋酸去氧皮质酮文献

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