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去甲斑蝥素

去甲斑蝥素用途

【用途一】
用作抗肿瘤药

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去甲斑蝥素名称

[ CAS 号 ]:
29745-04-8

[ 中文名 ]:
去甲斑蝥素

[ 英文名 ]:
(±)-Norcantharidin

[中文别名 ]:

exo-3,6-环氧六氢邻苯二甲酸酐

[英文别名 ]:

norcantharadin
4,10-dioxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
exo-3,6-Epoxyhexahydrophthalic Anhydride
MFCD00213361
Isocantharidin
demethyl cantharidin
endothallanhydride
Norcantharidin
Exo-7-oxabicyclo(2.2.1)h
(4R,7S)-hexahydro-4,7-epoxy-2-benzofuran-1,3-dione

去甲斑蝥素生物活性

[ 描述 ]:

(±)-Norcantharidin ((±)-NCTD),一种具有抗血管生成活性的化合物,可能用于抗癌治疗。(±)-Norcantharidin 通过抑制细胞增殖、诱导细胞凋亡和细胞周期阻滞、抗血管生成等作用,抑制肿瘤的发生。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[体外研究]

(？)-去甲斑蝥素(？)-NCTD)抑制HMC细胞增殖,诱导细胞凋亡,影响细胞周期[1]。

[参考文献]

[1]. Ye K, et al. Effect of norcantharidin on the proliferation, apoptosis, and cell cycle of human mesangialcells. Ren Fail. 2017 Nov;39(1):458-464.

去甲斑蝥素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
362.5±35.0 °C at 760 mmHg

[ 熔点 ]:
114-116ºC

[ 分子式 ]:
C₈H₈O₄

[ 分子量 ]:
168.147

[ 闪点 ]:
167.0±26.0 °C

[ 精确质量 ]:
168.042252

[ PSA ]:
52.60000

[ LogP ]:
-0.85

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.550

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

去甲斑蝥素MSDS

详细MSDS(安全技术说明书)

去甲斑蝥素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RN8400000

CHEMICAL NAME :: 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride, exo-

CAS REGISTRY NUMBER :: 29745-04-8

BEILSTEIN REFERENCE NO. :: 0084287

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-O4

MOLECULAR WEIGHT :: 168.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 35,823,1987

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去甲斑蝥素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RN8400000

[ 海关编码 ]:
2932999099

去甲斑蝥素上下游产品

去甲斑蝥素上游产品

去甲斑蝥素下游产品

去甲斑蝥素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

去甲斑蝥素文献

Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity.

J. Asian Nat. Prod. Res. 17 , 800-7, (2015)

Two new triterpenoid saponins, oleiferoside N and oleiferoside O, were isolated from the EtOH extract from the roots of Camellia oleifera C. Abel. Their structures were elucidated as 16α-acetoxy-21β,2...

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.

Sci. Rep. 5 , 11836, (2015)

Cantharidin is an active constituent of mylabris, a traditional Chinese medicine, and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle co...

A novel cantharidin analogN-Benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR

Biochem. Biophys. Res. Commun. 447(2) , 371-7, (2014)

Graphical abstract

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