呋喃
呋喃用途
主要用于制作大批量热芯盒工艺型芯的粘合剂
【用途二】
呋喃用作有机合成原料和溶剂。呋喃可用来制取吡咯、噻吩、四氢呋喃等，四氢呋喃是呋喃的重要衍生物，有许多重要用途。呋喃经醚化，还原得到2,5-二甲氧基二氢呋喃，经水解生成2-羟基-1,4-丁二醛，可用于合成法山莨菪碱的生产；当呋喃经醚化、还原，再经催化加氢得到2,5-二甲氧基四氢呋喃时，经水解生成丁二醛，则是合成另一种生物碱阿托品的原料。呋喃还用来生产消炎药甲苯酰吡各乙酸钠，每吨这种药物需消耗呋喃4.75t。
【用途三】
用作有机合成原料和溶剂。
呋喃名称
[ CAS 号 ]:
110-00-9
[ 中文名 ]:
呋喃
[ 英文名 ]:
Furan
[中文别名 ]:
[英文别名 ]:
- tetrole oxide
- Furan
- Tetrole
- Oxacyclopentadiene
- Furan [UN2389] [Flammable liquid]
- Oxole
- EINECS 214-757-1
- UN 2389
- Divinylene oxide
- MFCD00003242
呋喃物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
31.4±9.0 °C at 760 mmHg
[ 熔点 ]:
-85.6 °C
[ 分子式 ]:
C4H4O
[ 分子量 ]:
68.074
[ 闪点 ]:
-35.6±0.0 °C
[ 精确质量 ]:
68.026215
[ PSA ]:
13.14000
[ LogP ]:
1.38
[ 外观性状 ]:
透明至淡黄色液体
[ 蒸汽密度 ]:
2.35 (vs air)
[ 蒸汽压 ]:
605.2±0.1 mmHg at 25°C
[ 折射率 ]:
1.427
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放
[ 稳定性 ]:
Stable. Substances to be avoided include strong oxidising agents, acids, peroxides and oxygen. Highly flammable; can form explosive mixtures with air.
[ 水溶解性 ]:
insoluble
呋喃MSDS
呋喃毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LT8524000
- CHEMICAL NAME :
- Furan
- CAS REGISTRY NUMBER :
- 110-00-9
- BEILSTEIN REFERENCE NO. :
- 0103221
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 32
- MOLECULAR FORMULA :
- C4-H4-O
- MOLECULAR WEIGHT :
- 68.08
- WISWESSER LINE NOTATION :
- T5OJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3398 ppm/1H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/m3/1H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 234 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting Blood - hemorrhage
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 234 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting Blood - hemorrhage
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 240 mg/kg/16D-I
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3900 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - changes in thymus weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/m3/4H/60D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Liver - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/m3/2H/9W-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/m3/4H/26W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Vascular - BP lowering not characterized in autonomic section
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/m3/2H/30D-I
- TOXIC EFFECTS :
- Liver - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1950 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2730 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1040 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Liver - angiosarcoma
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4160 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3900 mg/kg
- SEX/DURATION :
- male 13 week(s) pre-mating female 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Maternal Effects - ovaries, fallopian tubes
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 184 mmol/L
- REFERENCE :
- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 13,89,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,393,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,393,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,393,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 34185 No. of Facilities: 25 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 244 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 34185 No. of Facilities: 14 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 35 (estimated) No. of Female Employees: 7 (estimated)
呋喃安全信息
[ 符号 ]:
GHS02, GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H224-H302 + H332-H315-H341-H350-H373-H412
[ 补充危害声明 ]:
May form explosive peroxides.
[ 警示性声明 ]:
P201-P210-P273-P281-P308 + P313
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R12;R19;R20/22;R38;R45;R48/22;R52/53;R68
[ 安全声明 (欧洲) ]:
S53-S45-S61
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
OB3870000
[ 包装等级 ]:
I
[ 危险类别 ]:
3
[ 海关编码 ]:
2932999060
呋喃合成路线
呋喃上下游产品
呋喃上游产品
呋喃下游产品
呋喃制备
1.由糠醛氧化得到2-呋喃甲酸，经脱羧后，即得呋喃。将2-呋喃甲酸加热至200-205℃（沸点左右），即分解为呋喃和二氧化碳。反应过程中，将升华的2-呋喃甲酸返回反应器，馏出的呋喃重新蒸馏，收集31-34℃馏分即得较纯的成品。收率约75%。工业上可由糠醛直接脱羰。反应所用的催化剂有硅酸铝、金属氧化物或氢氧化物以及合金或金属的混合物，如亚铬酸锌和锰的混合物，反应温度约400℃，收率90%。在大规模生产时收率可达74%。
精制方法：用5%氢氧化钾水溶液洗涤，无水硫酸钙或无水硫酸钠干燥，使用前在氢氧化钾或金属钠存在下蒸馏。若有过氧化物，可用硫酸氢钠和弱酸性硫酸亚铁水溶液洗涤除去。
呋喃海关
[ 海关编码 ]: 2932190090
[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
呋喃文献
Bioresour. Technol. 193 , 433-41, (2015)
Escherichia coli KJ122 was engineered to produce succinate from glucose using the wild type GalP for glucose uptake instead of the native phosphotransferase system (ptsI mutation). This strain now fer...
An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids.Macromol. Biosci. 15 , 965-78, (2015)
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioco...
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥138.0/500ml
联系人：刘佳
产品详情：呋喃
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：呋喃
公司名：广东翁江化学试剂有限公司
区域：韶关市翁源县
价格：
￥5600.0/20kg
￥560.0/500ml
联系人：朱丽丹
产品详情：呋喃
查看所有供应商请点击：
相关化合物
【呋喃】化源网提供呋喃CAS号110-00-9，呋喃MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询呋喃上化源网，专业又轻松。>>电脑版：呋喃
标题：呋喃_MSDS_用途_密度_呋喃CAS号【110-00-9】_化源网 地址：https://m.chemsrc.com/mip/cas/110-00-9_670773.html