甘露醇氮芥
甘露醇氮芥名称
[ CAS 号 ]:
576-68-1
[ 中文名 ]:
甘露醇氮芥
[ 英文名 ]:
mannomustine
[中文别名 ]:
[英文别名 ]:
- Mannit-lost [German]
- Mannomustin
- Mannitol nitrogen mustard
- Manomustina [INN-Spanish]
- Mannomustine [INN:BAN:DCF]
- Mannit-mustard [German]
- Mannit-Lost
- Mannomustinum [INN-Latin]
- BCM (cytostatic)
- mannomustine
甘露醇氮芥物理化学性质
[ 密度 ]:
1.353g/cm3
[ 沸点 ]:
541.9ºC at 760 mmHg
[ 熔点 ]:
278°C (rough estimate)
[ 分子式 ]:
C10H22Cl2N2O4
[ 分子量 ]:
305.19900
[ 闪点 ]:
281.5ºC
[ 精确质量 ]:
304.09600
[ PSA ]:
104.98000
[ 折射率 ]:
1.544
甘露醇氮芥毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2100000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,
- CAS REGISTRY NUMBER :
- 576-68-1
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4
- MOLECULAR WEIGHT :
- 305.24
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Cells - not otherwise specified
- DOSE/DURATION :
- 2900 nmol/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982
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