Chirality

Solution??phase synthesis and evaluation of tetraproline chiral stationary phases

Z Dai, G Ye, CU Pittman, T Li

文献索引：Dai, Zhi; Ye, Guozhong; Pittman Jr., Charles U.; Li, Tingyu Chirality, 2012 , vol. 24, # 4 p. 329 - 338

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被引用次数: 4

摘要

Abstract A protocol was developed for the solution-phase synthesis of multigram amounts of two 9-fluorenylmethoxycarbonyl (Fmoc)-protected tetraproline peptides. These tetraproline peptides were then attached to amino derivatized silica gel. The replacement of the Fmoc group with the trimethylacetyl group lead to two tetraproline chiral stationary phases (CSPs). A comparison of the chromatographic behavior of these two solution-phase-synthesized ...