Abstract A facile palladium-catalyzed synthesis of acridines has been realized by consecutive C= C double bond formation and C–N cross-coupling. A variety of functionalized acridines can be accessed from easily available o-dihalobenzenes and N- tosylhydrazones in a single operation. This one-pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine ...
[Lian, Yajing; Hummel, Joshua R.; Bergman, Robert G.; Ellman, Jonathan A. Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12548 - 12551]