New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl) methyl]-N-(4-piperidinyl)-1H-benzimidazol-2- …

…, J Torremans, M Janssen, RA Stokbroekx…

文献索引：Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943

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被引用次数: 43

摘要

The duration of action for a selected number of com-pounds was studied in the histamine lethality test in guinea pigs; 5 results are summarized in Table 111. Histamineand serotonin- induced cutaneous reactions tests in rats were performed as already described. 6 The results of these