… relationship of 2-(aminoalkyl)-2, 3, 3a, 8-tetrahydrodibenzo [c, f] isoxazolo [2, 3-a] azepine derivatives: a novel series of 5-HT 2A/2C receptor antagonists. Part 2

…, L Iturrino, E Matesanz, TF Meert, A Megens…

文献索引：Andres; Alcazar, Jesus; Alonso, Jose M.; Diaz, Adolfo; Fernandez, Javier; Gil, Pilar; Iturrino, Laura; Matesanz, Encarna; Meert, Theo F.; Megens, Anton; Sipido, Victor K. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 243 - 248

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被引用次数: 34

摘要

Following the programme started at Janssen Research Foundation searching for 5-HT2A/2C antagonists, we now report on the synthesis of a series of substituted 2- (Dimethylaminomethyl)-2, 3, 3a, 8-tetrahydrodibenzo [c, f] isoxazolo [2, 3-a] azepine derivatives. The 5-HT2A, 5-HT2C and H1 receptor affinities as well as the mCPP antagonistic activity of the compounds synthesised is described.