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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Monoamine oxidase and succinate dehydrogenase inhibitory properties of substituted 1, 3, 4??oxadiazole??2??thiones

N Soni, JP Barthwal, AK Saxena…

文献索引：Soni; Barthwal; Saxena; et al. Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 1 p. 29 - 32

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被引用次数: 22

摘要

Abstract Fifteen new 3-arylaminomethyl-5-(2-hydroxy-3, 5-dibromophenyl)-1, 3, 4- oxadiazole-2-thiones were synthesized and characterized by their sharp melting points, elemental analyses and ir spectra. These substituted oxadiazolylthiones were evaluated for their enzyme inhibitory activity. All compounds inhibited in vitro monoamine oxidase and succinate dehydrogenase activity of rat brain homogenates. The degree of monoamine ...

甲醛结构式

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione结构式

5-(2-Hydroxy-3,...

2,6-二氯苯胺结构式

2,6-二氯苯胺

~61%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)-结构式

1,3,4-Oxadiazol...

3,5-二溴-2-羟基苯甲酸甲酯结构式

3,5-二溴-2-羟基苯甲酸甲酯

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)-结构式

1,3,4-Oxadiazol...

水杨酸甲酯结构式

水杨酸甲酯

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)-结构式

1,3,4-Oxadiazol...

3,5-二溴水杨肼结构式

3,5-二溴水杨肼

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)-结构式

1,3,4-Oxadiazol...

六氢吡啶结构式

甲醛结构式

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione结构式

5-(2-Hydroxy-3,...

~77%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)-结构式

1,3,4-Oxadiazol...

3,5-二溴-2-羟基苯甲酸甲酯结构式

3,5-二溴-2-羟基苯甲酸甲酯

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)-结构式

1,3,4-Oxadiazol...

水杨酸甲酯结构式

水杨酸甲酯

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)-结构式

1,3,4-Oxadiazol...

3,5-二溴水杨肼结构式

3,5-二溴水杨肼

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)-结构式

1,3,4-Oxadiazol...

甲醛结构式

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione结构式

5-(2-Hydroxy-3,...

邻氨基苯乙醚结构式

邻氨基苯乙醚

~60%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

3,5-二溴-2-羟基苯甲酸甲酯结构式

3,5-二溴-2-羟基苯甲酸甲酯

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

水杨酸甲酯结构式

水杨酸甲酯

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

3,5-二溴水杨肼结构式

3,5-二溴水杨肼

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

甲醛结构式

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione结构式

5-(2-Hydroxy-3,...

N-甲基苯胺结构式

~71%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

3,5-二溴-2-羟基苯甲酸甲酯结构式

3,5-二溴-2-羟基苯甲酸甲酯

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

水杨酸甲酯结构式

水杨酸甲酯

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

3,5-二溴水杨肼结构式

3,5-二溴水杨肼

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one结构式

(6E)-2,4-dibrom...

3,5-二溴-2-羟基苯甲酸甲酯结构式

3,5-二溴-2-羟基苯甲酸甲酯

~80%

3,5-二溴水杨肼结构式

3,5-二溴水杨肼