e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Monoamine oxidase and succinate dehydrogenase inhibitory properties of substituted 1, 3, 4??oxadiazole??2??thiones

N Soni, JP Barthwal, AK Saxena…

Index: Soni; Barthwal; Saxena; et al. Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 1 p. 29 - 32

Full Text: HTML

Citation Number: 22

Abstract

Abstract Fifteen new 3-arylaminomethyl-5-(2-hydroxy-3, 5-dibromophenyl)-1, 3, 4- oxadiazole-2-thiones were synthesized and characterized by their sharp melting points, elemental analyses and ir spectra. These substituted oxadiazolylthiones were evaluated for their enzyme inhibitory activity. All compounds inhibited in vitro monoamine oxidase and succinate dehydrogenase activity of rat brain homogenates. The degree of monoamine ...

Formaldehyde Structure

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione Structure

5-(2-Hydroxy-3,...

2,6-Dichloroaniline Structure

2,6-Dichloroaniline

~61%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)- Structure

1,3,4-Oxadiazol...

methyl 3,5-dibromo-2-hydroxybenzoate Structure

methyl 3,5-dibr...

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)- Structure

1,3,4-Oxadiazol...

Methyl salicylate Structure

Methyl salicylate

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)- Structure

1,3,4-Oxadiazol...

3,5-dibromosalicylhydrazide Structure

3,5-dibromosali...

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(((2, 6-dichlorophenyl)amino)methyl)- Structure

1,3,4-Oxadiazol...

Piperidine Structure

Formaldehyde Structure

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione Structure

5-(2-Hydroxy-3,...

~77%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)- Structure

1,3,4-Oxadiazol...

methyl 3,5-dibromo-2-hydroxybenzoate Structure

methyl 3,5-dibr...

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)- Structure

1,3,4-Oxadiazol...

Methyl salicylate Structure

Methyl salicylate

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)- Structure

1,3,4-Oxadiazol...

3,5-dibromosalicylhydrazide Structure

3,5-dibromosali...

~%

1,3,4-Oxadiazole-2(3H)-thione, 5-(3,5-dibromo-2-hydroxyphenyl)-3-(1-pi peridinylmethyl)- Structure

1,3,4-Oxadiazol...

Formaldehyde Structure

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione Structure

5-(2-Hydroxy-3,...

o-Phenetidine Structure

~60%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

methyl 3,5-dibromo-2-hydroxybenzoate Structure

methyl 3,5-dibr...

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

Methyl salicylate Structure

Methyl salicylate

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

3,5-dibromosalicylhydrazide Structure

3,5-dibromosali...

~%

(6E)-2,4-dibromo-6-[4-[(2-ethoxyanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

Formaldehyde Structure

5-(2-Hydroxy-3,5-dibromophenyl)-1,3,5-oxadiazole-2-thione Structure

5-(2-Hydroxy-3,...

N-Methylaniline Structure

N-Methylaniline

~71%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

methyl 3,5-dibromo-2-hydroxybenzoate Structure

methyl 3,5-dibr...

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

Methyl salicylate Structure

Methyl salicylate

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

3,5-dibromosalicylhydrazide Structure

3,5-dibromosali...

~%

(6E)-2,4-dibromo-6-[4-[(N-methylanilino)methyl]-5-sulfanylidene-1,3,4-oxadiazolidin-2-ylidene]cyclohexa-2,4-dien-1-one Structure

(6E)-2,4-dibrom...

methyl 3,5-dibromo-2-hydroxybenzoate Structure

methyl 3,5-dibr...

~80%

3,5-dibromosalicylhydrazide Structure

3,5-dibromosali...