Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives

T Okaecwe, AJ Swanepoel, A Petzer, JJ Bergh…

文献索引：Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anel; Bergh, Jacobus J.; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4336 - 4347

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被引用次数: 9

摘要

A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and-B. In an attempt to discover additional caffeine derivatives with potent MAO inhibitory activities, and to contribute to the known structure–activity relationships of MAO inhibition by caffeine derived compounds, the present study investigates the MAO inhibitory potencies of series of 8- ...