Green Chemistry

“All water chemistry” for a concise total synthesis of the novel class anti-anginal drug (RS),(R), and (S)-ranolazine

DN Kommi, D Kumar, AK Chakraborti

文献索引：Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K. Green Chemistry, 2013 , vol. 15, # 3 p. 756 - 767

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被引用次数: 21

摘要

A novel strategy of 'all water chemistry'is reported for a concise total synthesis of the novel class anti-anginal drug ranolazine in its racemic (RS) and enantiopure [(R) and (S)] forms. The reactions at the crucial stages of the synthesis are promoted by water and led to the development of new water-assisted chemistries for (i) catalyst/base-free N-acylation of amine with acyl anhydride,(ii) base-free N-acylation of amine with acyl chloride,(iii) ...