雷诺嗪

• 常用名: 雷诺嗪
• 英文名: Ranolazine
• CAS号: 95635-55-5
• 分子量: 427.536
• 密度: 1.2±0.1 g/cm3
• 沸点: 624.1±55.0 °C at 760 mmHg
• 分子式: C₂₄H₃₃N₃O₄
• 熔点: 119-1200C
• 闪点: 331.2±31.5 °C

雷诺嗪用途

Ranolazine具有抗心律失常活性。

雷诺嗪名称

• 中文名: 雷诺嗪
• 英文名: Ranolazine
• 中文别名: N-(2,6-二甲基苯基)-4-[2-羟基-3-(2-甲氧苯氧基)丙基]-1-哌嗪乙酰胺

雷诺嗪生物活性

• 描述: Ranolazine具有抗心律失常活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病
  天然产物 >> 其他
• 参考文献:

  [1]. Hale, S.L. and R.A. Kloner, Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther, 2006. 11(4): p. 249-55.

  [2]. Fraser, H., et al., Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol, 2006. 41(6): p. 1031-8.

  [3]. Gould, H.J., 3rd, et al., Ranolazine attenuates behavioral signs of neuropathic pain. Behav Pharmacol, 2009. 20(8): p. 755-8.

  [4]. Casey, G.P., et al., Ranolazine attenuation of CFA-induced mechanical hyperalgesia. Pain Med, 2010. 11(1): p. 119-26.

雷诺嗪物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 624.1±55.0 °C at 760 mmHg
• 熔点: 119-1200C
• 分子式: C₂₄H₃₃N₃O₄
• 分子量: 427.536
• 闪点: 331.2±31.5 °C
• 精确质量: 427.247101
• PSA: 74.27000
• LogP: 3.47
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.586
• 储存条件: -20°C Freezer

雷诺嗪安全信息

• 危害码 (欧洲): Xi
• 危险品运输编码: UN 2811 6.1 / PGIII
• 海关编码: 2933990090

雷诺嗪海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

雷诺嗪英文别名

• (±)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine
• (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide
• RAN D
• Renexa
• 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]
• N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamid
• CVT 303
• N-(2,6-diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]pipérazin-1-yl}acétamide
• (±)-4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide
• 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine
• N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide
• Ranolazine
• N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]-1-piperazineacetamide
• [14C]-Ranolazine
• Ran4
• MFCD00864690
• 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6,dimethylphenyl)-aminocarbonylmethyl]-piperazine
• Ranexa
• N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide
• 1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-
• N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide