Evaluation of some thiosemicarbazones of arylidene ketones and analogues for anticonvulsant activities
JR Dimmock, SS Jonnalagadda, S Hussein…
文献索引：Dimmock, J. R.; Jonnalagadda, S. S.; Hussein, S.; Tewari, S.; Quail, J. W.; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 581 - 588
Abstract A number of thiosemicarbazones of arylidene and aryl ketones were prepared as candidate anticonvulsant agents. X-Ray crystallography of 4-(4-methylphenyl)-3-buten-2- one thiosemicarbazone (1a) revealed that it had the E configuration with respect to both olefinic and carbimino double bonds. Other structural features of this anticonvulsant compound were noted. Most of the compounds displayed activity in the MES and/or ...
