Assessing the substrate selectivities and enantioselectivities of eight novel Baeyer-Villiger monooxygenases toward alkyl-substituted cyclohexanones

…, P Rouvière, Q Cheng, JD Stewart

文献索引：Kyte, Brian G.; Rouviere, Pierre; Cheng, Qiong; Stewart, Jon D. Journal of Organic Chemistry, 2004 , vol. 69, # 1 p. 12 - 17

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被引用次数: 64

摘要

Genes encoding eight Baeyer-Villiger monooxygenases have recently been cloned from bacteria inhabiting a wastewater treatment plant. We have carried out a systematic investigation in which each newly cloned enzyme, as well as the cyclohexanone monooxygenase from Acinetobacter sp. NCIB 9871, was used to oxidize 15 different alkyl- substituted cyclohexanones. The panel of substrates included equal numbers of 2-, 3-, ...