Synthesis and antiproliferative activity of alkylphosphocholines

…, E Fasoli, D Losi, G Pedrocchi-Fantoni, S Riva…

文献索引：Agresta, Mandy; D'Arrigo, Paola; Fasoli, Ezio; Losi, Daniele; Pedrocchi-Fantoni, Giuseppe; Riva, Simona; Servi, Stefano; Tessaro, Davide Chemistry and Physics of Lipids, 2003 , vol. 126, # 2 p. 201 - 210

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被引用次数: 16

摘要

Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using ω-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA) and cytotoxicity on non-tumoral cells (MT2), used as markers of ...