Highly Stereoselective Synthesis of β-Amino Ketones via a Mannich Reaction Catalyzed by Cellulose Sulfuric Acid as a Biodegradable, Efficient, and Recyclable …

…, AS Fakhaei, A Amoozadeh, YS Hayeniaz

文献索引：Nemati, Firouzeh; Fakhaei, Amir Soheyl; Amoozadeh, Ali; Hayeniaz, Yaser Saeidi Synthetic Communications, 2011 , vol. 41, # 24 p. 3695 - 3702

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被引用次数: 13

摘要

Abstract The efficient use of cellulose sulfuric acid as a heterogeneous catalyst promotes three-component, one-pot Mannich reaction of various ketones, aromatic aldehydes, and aromatic amines in ethanol to make the corresponding β-amino ketones with high stereoselectivity in favor of the anti-isomer. This protocol has several advantages such as good yield, mild reaction conditions, no environmental hazards, and simple workup ...