7-Substituted 5-amino-1-cyclopropyl-6, 8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone …

JM Domagala, SE Hagen, CL Heifetz…

文献索引：Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, p. 503 - 506

全文：HTML全文

被引用次数: 39

摘要

(10) Japanese Patent JP57, 149,286; Chem. Abstr. l983, 98, 72117q.(11) Verbist, L. Pharm. Weekbl., Sci. Ed. 1986, 8, 22.(12) Belf, LJ; Buxton, MW; Basset, JF Tetrahedron 1967, 23, 4719. cyclopropyl-6, 7, 8-trifluoro-1, 4-dihydro-4-oxo-3-quinoline-carboxylic acid (9) by the general route reported by Chu. 14 This material was reacted with trifluoroacetic anhydride to give 10, which was alkylated at nitrogen with sodium hydride and methyl iodide, ...