7-Substituted 5-amino-1-cyclopropyl-6, 8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone …

JM Domagala, SE Hagen, CL Heifetz…

Index: Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, p. 503 - 506

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Citation Number: 39

Abstract

(10) Japanese Patent JP57, 149,286; Chem. Abstr. l983, 98, 72117q.(11) Verbist, L. Pharm. Weekbl., Sci. Ed. 1986, 8, 22.(12) Belf, LJ; Buxton, MW; Basset, JF Tetrahedron 1967, 23, 4719. cyclopropyl-6, 7, 8-trifluoro-1, 4-dihydro-4-oxo-3-quinoline-carboxylic acid (9) by the general route reported by Chu. 14 This material was reacted with trifluoroacetic anhydride to give 10, which was alkylated at nitrogen with sodium hydride and methyl iodide, ...