Enantiomerically pure organoseleno-1-arylethanols by enzymatic resolution with Candida antarctica lipase: Novozym 435

ÁT Omori, LF Assis, LH Andrade, JV Comasseto…

文献索引：Omori, Alvaro T.; Assis, Leonardo F.; Andrade, Leandro H.; Comasseto, Joao V.; Porto, Andre L.M. Tetrahedron Asymmetry, 2007 , vol. 18, # 9 p. 1048 - 1053

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被引用次数: 17

摘要

Racemic organoseleno-1-arylethanols were prepared by ortho-lithiation of arylethanols, followed by sequential reaction with elemental selenium and alkyl halides and by reaction of either aryldiazonium chlorides with diphenyldiselenide or with lithium and magnesium alkylselenolates. Enantiomerically enriched organoseleno-1-arylethanols were obtained by kinetic resolution of the racemic mixtures by esterification catalyzed by Candida antarctica ...