Enantiomerically pure organoseleno-1-arylethanols by enzymatic resolution with Candida antarctica lipase: Novozym 435

ÁT Omori, LF Assis, LH Andrade, JV Comasseto…

Index: Omori, Alvaro T.; Assis, Leonardo F.; Andrade, Leandro H.; Comasseto, Joao V.; Porto, Andre L.M. Tetrahedron Asymmetry, 2007 , vol. 18, # 9 p. 1048 - 1053

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Citation Number: 17

Abstract

Racemic organoseleno-1-arylethanols were prepared by ortho-lithiation of arylethanols, followed by sequential reaction with elemental selenium and alkyl halides and by reaction of either aryldiazonium chlorides with diphenyldiselenide or with lithium and magnesium alkylselenolates. Enantiomerically enriched organoseleno-1-arylethanols were obtained by kinetic resolution of the racemic mixtures by esterification catalyzed by Candida antarctica ...