Rational design of inhibitors of VirA–VirG two-component signal transduction

J Maresh, J Zhang, YL Tzeng, NA Goodman…

文献索引：Maresh, Justin; Zhang, Jin; Tzeng, Yih-Ling; Goodman, Nora A.; Lynn, David G. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3281 - 3286

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被引用次数: 10

摘要

VirA–VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4, 6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found ...