Scale-up synthesis of the dopamine uptake inhibitor GBR-12909
…, PM Sugathapala, J Robertson…
文献索引：Ironside, Michael D.; Sugathapala, Priyantha M.; Robertson, Jerod; Darey, Mark C.P.; Zhang, Jianzhong Organic Process Research and Development, 2002 , vol. 6, # 5 p. 621 - 627
1-[2-[Bis (4-fluorophenyl) methoxy] ethyl]-4-(3-phenylpropyl) piperazine (GBR-12909) is a dopamine uptake inhibitor. The development of a robust process for the preparation of this compound in kilogram quantities is described. The primary aims of the development work were to eliminate chromatographic purifications, to minimize the use of environmentally unacceptable reagents, and to improve the overall yield of the three-step convergent ...
