Scale-up synthesis of the dopamine uptake inhibitor GBR-12909

…, PM Sugathapala, J Robertson…

Index: Ironside, Michael D.; Sugathapala, Priyantha M.; Robertson, Jerod; Darey, Mark C.P.; Zhang, Jianzhong Organic Process Research and Development, 2002 , vol. 6, # 5 p. 621 - 627

Full Text: HTML

Citation Number: 2

Abstract

1-[2-[Bis (4-fluorophenyl) methoxy] ethyl]-4-(3-phenylpropyl) piperazine (GBR-12909) is a dopamine uptake inhibitor. The development of a robust process for the preparation of this compound in kilogram quantities is described. The primary aims of the development work were to eliminate chromatographic purifications, to minimize the use of environmentally unacceptable reagents, and to improve the overall yield of the three-step convergent ...