Tetrahedron

Facile preparation of amides from carboxylic acids and amines with ion-supported Ph 3 P

Y Kawagoe, K Moriyama, H Togo

文献索引：Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2013 , vol. 69, # 19 p. 3971 - 3977

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被引用次数: 14

摘要

Ion-supported Ph3P, 4-(diphenylphosphino) benzyltrimethylammonium bromide (IS-Ph3P), could be used for the facile amidation of a wide range of carboxylic acids with amines in the presence of bromotrichloromethane to provide the corresponding amides in good yields. In the present reaction, the desired amides were obtained in good yields with high purity by simple extraction of the reaction mixture with diethyl ether or chloroform and subsequent ...