Abstract The aerial parts of a new species from the genus Agathosma yielded skimmianine and two new alkaloids which were identified by means of spectral data and synthesis as 4, 6- dimethoxy-1-methyl-2 (1H)-quinolinone and 2, 6-dihydro-9-methoxy-2, 2, 6-trimethyl-5H- pyrano [3, 2c] quinolin-5-one. Further related structures were synthesized and a 2D NMR study on the eight synthetic structures enabled us to correct some of the data appearing in ...