艾拉莫德
更新时间：2025-08-25 23:12:41
采购访问：163次
| 常用名 | 艾拉莫德 | CAS号 | 123663-49-0 |
|---|---|---|---|
| 价格 | ￥需询单/1kg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品详情（用途，包装等）
英文别名 T 614 Ailamode Iguratimod IGURATIMOD IguratiMod (T 614) N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide 3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide CAS 123663-49-0 EINECS 808-127-0 化学式 C17H14N2O6S 分子量 374.37 InChI InChI=1/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20) 密度 1.52±0.1 g/cm3(Predicted)
熔点 238.0 to 242.0 °C 沸点 580.6±60.0 °C(Predicted) 闪点 304.9°C 蒸汽压 1.8E-13mmHg at 25°C 溶解度 DMSO (Slightly) 折射率 1.673 酸度系数 5.58±0.20(Predicted) 存储条件 under inert gas (nitrogen or Argon) at 2-8°C 外观 Solid 颜色 White to Off-White 体外研究 Iguratimod (T-614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC 50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod (0.1, 1, 10 μg/mL) inhibits bradykinin-stimulated PGE2 release from fibroblasts. Iguratimod suppresses the COX activity from bradykinin stimulated fibroblasts in a concentration-dependent manner, with an IC 50 of 48 μg/mL. Iguratimod (10 and 30 μg/mL) also dose-dependently inhibits COX-2 mRNA levels. In addition, Iguratimod potently inhibits macrophage migration inhibitory factor (MIF) with an IC 50 of 6.81 μM. Iguratimod is synergetic with glucocorticoids in vitro. 体内研究 Iguratimod (5 or 20 mg/kg) shows analgesic effect, significantly improves the pain withdrawal threshold of the left hind paw in dose-dependent manner in rats. Iguratimod (5 or 20 mg/kg) reduces the elevation of pERK1/2 and c-Fos in the spinal cord induced by cancer cell inoculation. Iguratimod also dose-dependently decreases the IL-6 levels in rats. In Iguratimod-treated rats, the activity of osteoclasts is weaker than the control group. Iguratimod (20 mg/kg i.p.) shows significantly increased survival in BALB/c mice that are vulnerable to endotoxemia, and attenuates TNFα release measured in serum isolated 90 min post-LPS administration in wild-type C57BL/6 mice. 更多
|
江西瑞威尔生物科技有限公司
认证状态：已认证供应商
商品数：403件
电话：4008802824
地址：江西省吉安市峡江县仁和镇新陂村官山组
地区： 江西省 吉安市 峡江县
联系人：李经理
联系人电话：13297919155
邮件：2929362908@qq.com
网址：https://www.ruiweier.cn/
主要市场：
年贸易额：
外贸占销售比例：
主要合作伙伴：
- 江西瑞威尔生物科技有限公司
- 江西省 吉安市 峡江县
- 产品名：艾拉莫德
- 价格： ￥需询单/1kg
- 纯度：98.0%
- 备货期：1天
- 联系人：李经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：艾拉莫德
- 价格： ￥319.9/1g ￥113.9/250mg ￥30.9/25mg ￥31.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
查看所有供应商和价格请点击：
参考价格：￥748.8/5mg