Grapiprant

更新时间：2025-09-18 10:29:43

Grapiprant结构式	常用名	Grapiprant	英文名	grapiprant
	CAS号	415903-37-6	分子量	491.605
	密度	1.3±0.1 g/cm3	沸点	N/A
	分子式	C₂₆H₂₉N₅O₃S	熔点	N/A
	MSDS	N/A	闪点	N/A

Grapiprant用途

Grapiprant是一种选择性EP4受体拮抗剂, 生理配体为前列腺素E2（PGE2）。

中文名	Grapiprant
英文名	Grapiprant
英文别名	更多

描述	Grapiprant是一种选择性EP4受体拮抗剂, 生理配体为前列腺素E2(PGE2)。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体研究领域 >> 代谢疾病
参考文献	[1]. Vito VD, et al. Detection and quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in canine plasma by HPLC with spectrofluorimetric detection. J Pharm Biomed Anal. 2016 Jan 25;118:251-8. [2]. Rausch-Derra LC, et al. Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment of osteoarthritic pain and inflammation, in healthy dogs. Am J Vet Res. 2015 Oct;76(10):853-9. [3]. Rahman MJ, et al. Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. JCI Insight. 2018 Feb 8;3(3). pii: 97843.

描述

Grapiprant是一种选择性EP4受体拮抗剂, 生理配体为前列腺素E2(PGE2)。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 代谢疾病

参考文献

[1]. Vito VD, et al. Detection and quantification of the selective EP4 receptor antagonist CJ-023423 (grapiprant) in canine plasma by HPLC with spectrofluorimetric detection. J Pharm Biomed Anal. 2016 Jan 25;118:251-8.

[2]. Rausch-Derra LC, et al. Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment of osteoarthritic pain and inflammation, in healthy dogs. Am J Vet Res. 2015 Oct;76(10):853-9.

[3]. Rahman MJ, et al. Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. JCI Insight. 2018 Feb 8;3(3). pii: 97843.

密度	1.3±0.1 g/cm3
分子式	C₂₆H₂₉N₅O₃S
分子量	491.605
精确质量	491.199097
LogP	4.56
InChIKey	HZVLFTCYCLXTGV-UHFFFAOYSA-N
SMILES	CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
折射率	1.647
储存条件	2-8℃

实验名称：Aqueous solubility of the compound at pH 6
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3744256

实验名称：Drug metabolism in human hepatic microsomes
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3744255

实验名称：Drug metabolism in rat hepatic microsomes
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3744254

实验名称：Aqueous solubility of compound at pH 6 at 2 mM after 20 hrs by HPLC
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3796825

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808149

实验名称：Analgesic activity in po dosed rat assessed as inhibition of carrageenan-induced mech...
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL3997118

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate
来源：ChEMBL
靶标：Histone deacetylase 6
External Id：CHEMBL4808150

实验名称：Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhi...
来源：ChEMBL
靶标：Prostaglandin E2 receptor EP4 subtype
External Id：CHEMBL3744252

实验名称：Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of P...
来源：ChEMBL
靶标：Prostaglandin E2 receptor EP4 subtype
External Id：CHEMBL3744251

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N-{2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl}-N'-[(4-methylphenyl)sulfonyl]urea

CJ-023,423

MR10A7

N-({2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl}carbamoyl)-4-methylbenzenesulfonamide

grapiprant

RQ-00000007

AAT-007

UNII:J9F5ZPH7NB

2-Ethyl-4,6-dimethyl-1-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-1H-imidazo[4,5-c]pyridine

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上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：Grapiprant (CJ-023,423)
纯度：98.0%
价格：￥6399.9/100mg ￥1399.9/10mg ￥9999.9/200mg ￥2499.9/25mg
联系人：阿拉丁
联系电话：400-620-6333
阿拉丁：推动发现，推进科学

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：Grapiprant
纯度：99.0%
价格：
联系人：徐经理
联系电话：13311869306
化学行业ERP CRM 及小程序等系统搭建，欢迎咨询

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本网页内容来自不同专业数据源，如对内容有疑义，欢迎联系service1@chemsrc.com。