Tofogliflozin(hydrate)
更新时间：2026-07-13 01:47:31
采购访问：9次
| 常用名 | 托格列净 | CAS号 | 1201913-82-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Tofogliflozin(CSG-452) hydrate is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2.IC50 value: 2.9/14.9/6.4 nM(human/rat/mouse SGLT2) [1]Target: SGLT2 inhibitorin vitro: Tofogliflozin competitively inhibited SGLT2 in cells overexpressing SGLT2, and K(i) values for human, rat, and mouse SGLT2 inhibition were 2.9, 14.9, and 6.4 nM, respectively. The selectivity of tofogliflozin toward human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1 was the highest among the tested SGLT2 inhibitors under clinical development [1]. tofogliflozin was catalyzed to the primary hydroxylated derivative (M4) by CYP2C18, CYP4A11 and CYP4F3B, then M4 was oxidized to M1. 3. Tofogliflozin had no induction potential on CYP1A2 and CYP3A4 [4].in vivo: A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. In db/db mice, 4-week tofogliflozin treatment reduced glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test 4 days after the final administration [1]. Tofogliflozin (400 ng/ml) induced UGE of about 2 mg/kg per min and increased EGP by 1-2 mg/kg per min, resulting in PG in the normal range [2]. Tofogliflozin suppressed plasma glucose and glycated Hb and preserved pancreatic beta-cell mass and plasma insulin levels. No improvement of glycaemic conditions or insulin level was observed with losartan treatment [3]. 物理化学性质： CAS号：1201913-82-7 常用中文名：托格列净 常用英文名：Tofogliflozin (hydrate) 分子式：C22H28O7 分子量：404.45400 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
上海念兴实业有限公司
认证状态：已认证供应商
商品数：403768件
电话：18916513247
地址：2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市 上海市 普陀区
联系人：小陈
联系人电话：0086-021-52280163
邮件：sales@echemcloud.com
网址：http://www.echemcloud.com
主要市场：
年贸易额：
外贸占销售比例：
主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：托格列净一水合物（CSG 452 hydrate）
- 价格： ￥883.9/5mg ￥759.9/1ml ￥6629.9/100mg ￥2862.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
2881459338
复制
- 苏州市森菲达化工有限公司
- 江苏省 苏州市 相城区
- 产品名：托格列净
- 价格： ￥需询单/200kg
- 纯度：98.0%
- 备货期：需询单
- 联系人：程经理
3912721726
复制
18796480002
复制
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：TOFOGLIFLOZIN
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
1092734927
复制
15871494362
复制
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Tofogliflozin(hydrate)
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
351666998
复制
133 1186 9306
复制
查看所有供应商和价格请点击：
参考价格：$110/10mM*1mLinDMSO