托格列净

• 常用名: 托格列净
• 英文名: Tofogliflozin (hydrate)
• CAS号: 1201913-82-7
• 分子量: 404.45400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₈O₇
• 熔点: N/A
• 闪点: N/A

托格列净用途

Tofogliflozin(CSG-452)是SGLT2高效选择性抑制剂，对人源、大鼠和小鼠SGLT2的Ki值分别为2.9、14.9和6.4nM。

托格列净名称

• 中文名: 托格列净
• 英文名: (3S,3'R,4'S,5'S,6'R)-5-[(4-ethylphenyl)methyl]-6'-(hydroxymethyl)spiro[1H-2-benzofuran-3,2'-oxane]-3',4',5'-triol,hydrate

托格列净生物活性

• 描述: Tofogliflozin(CSG-452)是SGLT2高效选择性抑制剂,对人源、大鼠和小鼠SGLT2的Ki值分别为2.9、14.9和6.4nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> SGLT
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

  [2]. Nagata T, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-31.

  [3]. Yamane M, et al. In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP. Xenobioti

  [4]. Nagata T, et al. Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

托格列净物理化学性质

• 分子式: C₂₂H₂₈O₇
• 分子量: 404.45400
• 精确质量: 404.18400
• PSA: 108.61000
• LogP: 0.93230
• InChIKey: ZXOCGDDVNPDRIW-NHFZGCSJSA-N
• SMILES: CCc1ccc(Cc2ccc3c(c2)C2(OC3)OC(CO)C(O)C(O)C2O)cc1.O
• 外观性状: 粉末
• 储存条件: -20℃

托格列净靶点实验

查看更多实验

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实验名称：Hypoglycemic activity in C57BL/6J mouse assessed as blood glucose AUC (0 to 2 hrs) at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4368042

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托格列净英文别名

• CSG452
• Tofogliflozin hydrate (JAN)
• (1S,3'R,4'S,5'S,6'R)-6-((4-Ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol monohydrate
• (1S,3'R,4'S,5'S,6'R)-6-((4-Ethylphenyl)methyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro(2-benzofuran-1,2'-pyran)-3',4',5'-triol monohydrate
• Tofogliflozin (USAN)
• Tofogliflozin [USAN:INN]
• UNII-P8DD8KX4O4
• Tofogliflozin (hydrate)