MK2-IN-1?
更新时间：2024-07-15 12:31:24
采购访问：23次
| 常用名 | MK2-IN-1 | CAS号 | 1314118-92-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.IC50 value: 0.11 uM [1]Target: MAPKAPK2(MK2) inhibitorMK2-IN-1 was profiled for kinase selectivity by screening against a broad panel of 150 protein kinases at a concentration of 10 μM, and only CK1γ3 was significantly inhibited at greater than 50%. MK2-IN-1 inhibited pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion. MK2-IN-1 also dose dependently inhibited IL1β-stimulated matrixmetalloprotease (MMP)13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures. Of note, given its high degree of selectivity, our data suggest that MK2-IN-1 may be an excellent pharmacologic tool for specifically exploring and validating MK2 biology [3]. 物理化学性质： CAS号：1314118-92-7 常用中文名：MK2-IN-1 常用英文名：MK2-IN-1 分子式：C27H25ClN4O2 分子量：472.966 密度：1.3±0.1 g/cm3 沸点：699.2±55.0 °C at 760 mmHg 熔点：N/A 闪点：376.7±31.5 °C 储存条件：2-8℃ |
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