2,3-双(4-羟苯基)丙腈
更新时间：2024-07-15 12:32:03
采购访问：91次
| 常用名 | 2,3-双(4-羟苯基)丙腈 | CAS号 | 1428-67-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Diarylpropionitrile(DPN) is a non-steroidal estrogen receptor β(ER β) selective ligand.IC50 value:Target: ER β ligandin vitro: Pre-treatment with 1-100 nM DPN significantly decreased neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2, thereby mitigating apoptotic morphological alterations. DPN pre-treatment decreased the expression levels of pro-inflammatory cytokines IL-1β and IL-6 through attenuation of Aβ1-42-induced phosphorylation of mitogen-activated protein kinases JNK and p38. In addition, DPN enhanced ERK1/2 and Akt phosphorylation depressed by Aβ1-42 [1]. ERβ was expressed in RAW264.7 cells, and DPN statistically significantly decreased LPS-induced RANTES production in RAW264.7 cells. Small interfering RNA targeting the ERβ gene inhibited the effect of DPN on RANTES production. In addition, DPN inhibited nuclear translocation and phosphorylation of p65 by inhibiting IκB degradation and thus prohibited the activation of nuclear factor κB (NF-κB) [3].in vivo: DPN treatment during EAE did not attenuate demyelination, only partially improved axon conduction, and did not activate the phosphatidylinositol 3-kinase/serine-threonine-specific protein kinase/mammalian target of rapamycin signaling pathway in ERβ CKO mice [2]. 物理化学性质： CAS号：1428-67-7 常用中文名：2,3-双(4-羟苯基)丙腈 常用英文名：2,3-bis(4-hydroxyphenyl)propionitrile 分子式：C15H13NO2 分子量：239.269 密度：1.3±0.1 g/cm3 沸点：449.4±35.0 °C at 760 mmHg 熔点：203°C 闪点：225.6±25.9 °C 储存条件：-20°C |
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- 产品名：2,3-双(4-羟苯基)丙腈
- 价格： ￥478.9/10mg ￥1852.9/50mg ￥543.0/10mg ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：2,3-双(4-羟苯基)丙腈
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$106/10mM*1mLinDMSO