化合物YX-2-107
更新时间：2026-01-14 18:38:24
采购访问：9次
| 常用名 | YX-2-107 | CAS号 | 2417408-46-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.09% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： YX-2-107 is a CRBN-recruiting and specific CDK6-degrading PROTAC with IC50 of 0.69 and 4.4 nM for CDK4 and CDK6 in vitro, selectively degardes CDK6 in Ph+ BV173 ALL cells with a degradation constant of 4 nM.YX-2-107 does not affect expression of IKZF1 and IKZF3, and does not degarde CDK4 protein.YX-2-107 inhibits S-phase entry, cell proliferation, RB phosphorylation, and FOXM1 expression and induces the selective degradation of CDK6 in Ph+ BV173 and SUP-B15 cells.|PROTAC YX-2-107 is bioavailable in mice and pharmacologically active in suppressing Ph+ ALL proliferation in a mouse xenograft of Ph+ ALL, comparable or superior to that of the CDK4/6 enzymatic inhibitor palbociclib. 物理化学性质： CAS号：2417408-46-7 常用中文名：YX-2-107 常用英文名：YX-2-107 分子式：C45H51N11O9 分子量：889.971 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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