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乳清酸

更新时间:2024-07-15 12:36:11 采购访问:13次

常用名 乳清酸 CAS号 65-86-1
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Orotic acid (OA) is an intermediate in pyrimidine metabolism.IC50 Value: Target: Nucleoside antimetabolite/analogin vitro: OA increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].in vivo: male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of OA (a 300-mg tablet of OA methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with OA resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. The increases of hepatic OA and betaine levels in OA feeding rats was also found when compared to the normal rats [3]. Feeding 1% OA with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. OA-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to OA-induced lipogenesis because of little if any response in AMPK and downstream effectors [4].
物理化学性质:
CAS号:65-86-1
常用中文名:乳清酸
常用英文名:Orotic acid
分子式:C5H4N2O4
分子量:156.096
密度:1.8±0.1 g/cm3
沸点:656.9±65.0 °C at 760 mmHg
熔点:>300°C
闪点:351.1±34.3 °C
储存条件:室温

供应商信息

上海念兴实业有限公司 认证供应商

认证状态:已认证供应商
商品数:403768件
电话:18916513247
地址:2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区: 上海市 上海市 普陀区
联系人:小陈
联系人电话:0086-021-52280163
邮件:sales@echemcloud.com
网址:http://www.echemcloud.com
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参考价格:$66/10mM*1mLinDMSO
其他供应商价格:
2025-02-25 乳清酸(无水)(Orotic acid)
价格:¥需询单
2022-02-19 乳清酸
价格:¥29.9
2019-03-05 乳清酸
价格:¥318.0
2024-07-15 乳清酸
价格:需询单
2016-06-27 乳清酸
价格:¥80.0
2017-08-06 乳清酸
价格:¥需询单
2024-06-15 乳清酸
价格:¥需询单
2018-01-09 乳清酸
价格:¥需询单
2024-12-23 Orotic Acid Anhydrous
价格:$21.5
2024-05-23 乳清酸
价格:¥需询单

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