| 常用名 | 乳清酸 | CAS号 | 65-86-1 |
|---|---|---|---|
| 价格 | ¥需询单/1kg ¥需询单/10kg ¥需询单/500kg ¥需询单/1ton | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 有现货 |
| 产品详情(用途,包装等)
用途: Orotic acid (OA) is an intermediate in pyrimidine metabolism.IC50 Value: Target: Nucleoside antimetabolite/analogin vitro: OA increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].in vivo: male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of OA (a 300-mg tablet of OA methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with OA resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. The increases of hepatic OA and betaine levels in OA feeding rats was also found when compared to the normal rats [3]. Feeding 1% OA with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. OA-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to OA-induced lipogenesis because of little if any response in AMPK and downstream effectors [4]. 物理化学性质: CAS号:65-86-1 常用中文名:乳清酸 常用英文名:Orotic acid 分子式:C5H4N2O4 分子量:156.096 密度:1.8±0.1 g/cm3 沸点:656.9±65.0 °C at 760 mmHg 熔点:>300°C 闪点:351.1±34.3 °C 储存条件:室温 |