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乳清酸(无水)(Orotic acid)

更新时间:2025-12-17 18:55:46 采购访问:16次

常用名 乳清酸 CAS号 65-86-1
价格 ¥需询单/1kg ¥需询单/10kg ¥需询单/500kg ¥需询单/1ton 纯度 99.0%
备货期 需询单 库存 有现货
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用途:
Orotic acid (OA) is an intermediate in pyrimidine metabolism.IC50 Value: Target: Nucleoside antimetabolite/analogin vitro: OA increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].in vivo: male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of OA (a 300-mg tablet of OA methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with OA resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. The increases of hepatic OA and betaine levels in OA feeding rats was also found when compared to the normal rats [3]. Feeding 1% OA with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. OA-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to OA-induced lipogenesis because of little if any response in AMPK and downstream effectors [4].
物理化学性质:
CAS号:65-86-1
常用中文名:乳清酸
常用英文名:Orotic acid
分子式:C5H4N2O4
分子量:156.096
密度:1.8±0.1 g/cm3
沸点:656.9±65.0 °C at 760 mmHg
熔点:>300°C
闪点:351.1±34.3 °C
储存条件:室温

供应商信息

成都百事兴科技实业有限公司

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商品数:50件
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成都百事兴科技实业有限公司成立于2003年,是一家细胞培养基原料、氨基酸衍生物、维生素和医药中间体研发、生产、销售为一体的高新技术企业。公司掌握多项关键核心技术,拥有发明专利13项、实用新型专利16项,酪氨酸二钠、乳清酸无溴法生产填补了国内空白。
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参考价格:$66/10mM*1mLinDMSO
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